IUPAC name: (3S, 4R)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl) methyl]-2(3-H)-furanone-hydrochloride

Assay: Perchloric acid titration: Between 98,5% and 101,0% (USP) Sodium hydr. titration: Between 99,0% and 101,0% (BP - Ph.Eu.)

Product Origins: Extracted from the leaves of the South American plants Pilocarpus jaborandi and Pilocarpus microphyllus, Pilocarpine HCL is used predominantly for the treatment of eye disorders and has also recently been indicated for use in the treatment of dry mouth syndrome.

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Therapeutic Applications: Cholinomimetic drug with primarily the muscarinic effects of acetylcholine. Pilocarpine is used primarily in the treatment of open-angle glaucoma and detached retina where it is believed to be effective in the reduction of intra-ocular pressure. Applications indicate Pilocarpine may also be useful to constrict the pupil in order to counteract the effect of mydriatic (pupil dilating) drugs such as atropine and phenylephrine.

Pilocarpine HCL is also indicated for the treatment of radiation induced xerostomia (dry mouth) in patients with cancer of the head and neck. Pilocarpine HCL is also a stimulant to the excretory glands and can act to increase bodily secretions including bronchial, nasal, mammory, salivary and to reduce severe bodily sweating.

Therapeutical Categories: Antiglaucoma agent, Miotic (VET.), Miotic, Gastric secretory stimulant, Anti sweating.